Estimation of body composition in muscular dystrophy by MRI and stereology
نویسندگان
چکیده
منابع مشابه
Phospholipid composition and metabolism in mouse muscular dystrophy.
1. The composition and metabolism of phospholipids were studied in various tissues from both normal and dystrophic mice of the 129 ReJ strain. Phospholipids extracted from forebrain, spinal cord, sciatic nerve and plasma were fractionated by t.l.c. and measured. 2. Very significant alterations were found in the choline phospholipids from these tissues, except forebrain. Plasma phosphatidylcholi...
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OBJECTIVE The aim of this study was to evaluate the usefulness of magnetic resonance imaging (MRI) in detecting the progression of Duchenne muscular dystrophy (DMD) by quantification of fat infiltration (FI) and muscle volume index (MVI, a residual-to-total muscle volume ratio). METHODS Twenty-six patients (baseline age: 5-12 years) with genetically proven DMD were longitudinally analyzed wit...
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Duchenne muscular dystrophy (BMD) is an inherited X-link disease. The incidence of this muscle-wasting disease is 1:5000 male live births. Mutation in the gene coding for dystrophin is the main cause of BMD. Most cases of this disease succumb to respiratory and cardiac failure in 3rd to 4th decades. The slow progression of BMD and recent achievement of gene therapies make it as an appropriate c...
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INTRODUCTION Whole-body-vibration training is used to improve muscle strength and function and might therefore constitute a potential supportive therapy for neuromuscular diseases. OBJECTIVE To evaluate safety of whole-body vibration training in ambulatory children with Duchenne muscular dystrophy (DMD) and spinal muscular atrophy (SMA). METHODS 14 children with DMD and 8 with SMA underwent...
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OBJECTIVE In boys with Duchenne muscular dystrophy (DMD), (1)H MRI suggested muscular edema before fatty degeneration. Using specific (23)Na MRI sequences, we tested the hypothesis that the edema is caused by an osmotic effect due to increased myoplasmic Na(+) content rather than inflammation that would lead to extracellular edema. METHODS Eleven patients with DMD (mean age, 10 ± 5 years) and...
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ژورنال
عنوان ژورنال: Journal of Magnetic Resonance Imaging
سال: 2000
ISSN: 1053-1807,1522-2586
DOI: 10.1002/1522-2586(200009)12:3<467::aid-jmri13>3.0.co;2-g